Plasmid & Chromosome Dynamics

July 22-27, 2001
Colby-Sawyer College
New London, NH

Gary Karpen, Chair
KARPEN@SALK.EDU

Sunday July 22
I. Chromosome and Nuclear Structure 1
Chair: Gary Karpen
7:15 PMWELCOME
7:30 PMJoanna Bridger, Brunel University, UK
"Interphase Chromosome Positioning - What's Involved?"
8 PM John Marko, University of Illinois, Chicago
``Micromechanical Experiments on Mitotic Chromosomes"
8:30 PMNancy Kleckner, Harvard U, Cambridge
"A Physico-mechanical view: chromosome breathing with resultant imposition and relief of stress governs chromosome activity"
9 PM Patrick Higgins, U of Alabama, Birmingham
"DNA Dynamics and Domain Structure in Bacterial Chromosomes"
9:30 PMBAR
Monday July 23
II. Chromosome and Nuclear Structure 2
Chair: Titia de Lange
9 AM Alexei Tulin, Carnegie Inst of Washington, Baltimore
"Developmental Functions of ADP-ribosylation"
9:30 AMLenny Guarente, MIT, Cambridge
"Sir2 regulates aging in yeast and worms"
10 AM John Moran, U of Michigan Medical School, Ann Arbor
"Studies of a Human Transposon"
10:30 AMBREAK & PHOTO
III. Telomeres
Chair: Abby Dernburg
11 AM Titia de Lange, Rockefeller U, New York
"Protection and Maintenance of Human Telomeres"
11:30 AMJulia Cooper, U of Colorado Health Science Center, Denver
"Telomeres and the Control of Cell Division"
12 PM Virginia Zakian, Princeton U
"Telomere Maintenance in Yeast"
12:30 PMLUNCH
4:30 PMPOSTER SESSION
6 PM DINNER
IV. DNA and Chromatin Replication
Chair: Allan Spradling
7:30 PM Saleem Khan, U of Pittsburgh School of Medicine
"DNA-protein Interactions during the Initiation and termination of Plasmid Rolling Circle Replication"
8 PM Elliot Crooke, Georgetown U Med Center, Washington DC
"DnaA Protein-Membrane Interactions in the Replication of the E. coli Chromosome."
8:30 PMJorge Schvartzman, Centro de Investigaciones Biologicas, Madrid, Spain
"In Partially Replicated Plasmids Positive Supercoiling Leads to Replication Fork Reversal"
9 PM K. Raghuraman, U of Washington, Seattle
"The Dynamics of Chromosome Replication in Yeast"
Tuesday July 24
V. Condensation and Cohesion
Chair: Rebecca Heald
9 AM Nancy Trun, Duquesne University, Pittsburgh
"Structure/function analysis of CspE, a small, bi-functional nucleic acid binding protein involved in chromosome folding"
9:30 AMTatsuya Hirano, Cold Spring Harbor Labs
"Mechanisms of chromosome condensation from bacteria to humans"
10 AM Nick Cozzarelli, U of California, Berkeley
"Mechanisms of chromosome condensation from bacteria to humans"
10:30 AM BREAK
11 AM Hironori Funabiki, Harvard U, Cambridge
"Mining chromosomes in Xenopus egg extracts"
11:30 AM Kirsten Hagstrom, U of California, Berkeley
"Mitotic Chromosome Condensation and Segregation by a Conserved Protein Complex"
12 PM Terry Orr-Weaver, Whitehead Institute/MIT, Cambridge
"Regulation of DNA replication and chromosome segregation in Drosophila"
12:30 PMLUNCH
4:30 PM POSTER SESSION
6 PM DINNER
VI. Plasmid and Chromosome Segregation 1
Chair: Saleem Khan
7:30 PM Stuart Austin, NCI-FCRDC, Frederick
"Segregation of the P1 plasmid by time-lapse photomicroscopy"
8 PM Alan Grossman, MIT, Cambridge
"DNA replication and chromosome partitioning in bacteria"
8:30 PMBarbara Funnell, U of Toronto, Toronto, Canada
"The action of ParA and ParB in P1 plasmid partition"
9 PM David Lane, CNRS, Toulouse, France
"The Role of SopA ATPase in Autoregulation and in Partition of Plasmid F"
9:30 PMBAR
Wednesday July 25
VII. Plasmid and Chromosome Segregation 2
Chair: Barbara Funnell
9 AM Joe Pogliano, U of California, San Diego
"Segregation of multicopy plasmids in bacteria"
9:30 AMSoundarapandian Velmuragan, U of Texas, Austin
"Dynamics of 2 Micron Plasmid Segregation in Yeast by Time-Lapse Fluorescence Microscopy"
10 AM Ken Marians, Mem. Sloan-Kettering Cancer Center, NY
"An Interaction between Topoisomerase IV and the Replication Machinery that Affects Chromosome Segregation in vivo"
10:30 AM BREAK
VIII. Centromeres and Kinetochores 1
Chair: Kevin Sullivan
11 AM Paul Kaufman, Lawrence Berkeley Natl Labs, UC Berkeley
"Function of Chromatin Assembly Proteins at the Yeast Centromere."
11:30 AMInes Pinto, U of Arkansas, Fayetteville
"The Role of Centromeric Chromatin during Chromosome Segregation in S. cerevisiae"
12 PM Pam Meluh, Mem. Sloan-Kettering Cancer Center, NY
"The Smt3p/SUMO-1 pathway impacts genomic stability in yeast"
12:30 PMLUNCH
4:30 PM POSTER SESSION
6 PM DINNER
IX. Centromeres and Kinetochores 2
Chair: Don Cleveland
7:30 PMJanet Partridge, MRC Human Genetics Unit, Edinburgh, UK
"A Cis-acting Element from Fission Yeast Centromeres Mediates Histone H3 Methylation and Recruitment of Silencing Factors at Ectopic Sites"
8 PM Beth Sullivan, The Salk Institute, La Jolla
"FISHing and ChIPing at Drosophila centromeres"
8:30 PMKevin Sullivan, Scripps Research Institute, La Jolla
"Assembly and Post-translational Modification of Kinetochore Chromatin: A Tale of Two Templates"
9 PM Daphne Preuss, U of Chicago
"The Arabidopsis Centromeres: From DNA Sequence to Function"
9:30 PMBAR
Thursday July 26
X. Centromeres and Kinetochores 3
Chair: Terry Orr-Weaver
9 AM Peter Warburton, Mount Sinai School of Medicine, New York
"Expression of CENP-B/CENP-A fusion proteins in mammalian cells containing ectopic alpha satellite DNA"
9:30 AM Don Cleveland, Ludwig Institute, U of California, San Diego
"Centromeres, CENP-E, Mps1, and the Mitotic Checkpoint"
10 AM Rebecca Heald, U of California, Berkeley
"Centromeres: Who Needs Em? The Role of Non-centromeric Chromatin in Spindle Assembly"
10:30 AM BREAK
XI. Meiosis 1
Chair: Pat Hunt
11 AM Sean Burgess, U of California, Davis
"Probing the three-dimensional space of the meiotic nucleus in yeast using site-specific recombination"
11:30 AMKaiming Sun, Brandeis University
"Exploring Chromosome Architecture by Studying Recombination"
12 PM Vince Guacci, Fox Chase Cancer Center, Philadelphia
"The Budding Yeast PDS5 Gene Encodes a Chromosomal Protein Required for Chromatid Cohesion and Condensation during Meiosis"
12:30 PMLUNCH
4:30 PM POSTER SESSION
6 PM DINNER
XII. Meiosis 2
Chair: Julia Cooper
7:30 PMScott Hawley, U of California, Davis
"Chromosome Pairing and Segregation in Drosophila females"
8 PM Mónica Colaiácovo, Stanford U, Palo Alto
"Assembly and Function of the Synaptonemal Complex in C. elegans Meiosis"
8:30 PMAbby Dernburg, Lawrence Berkeley Nat. Labs, UC Berkeley
"Sex and the Single Pairing Center"
9 PM Pat Hunt, Case Western Reserve U, Cleveland
"Meiotic chromosome segregation in the human female"
9:30 PMBAR

Copyright © 2001 Gordon Research Conferences
Last Updated: 8/7/01 by Jeff Carroll