Cell Proliferation, Molecular & Genetic Basis Of June 26 - July 1, 2005 Chair: Michael Tyers |
Cell proliferation, which depends on the intimately linked processes of growth and division, is a fundamental systems-level attribute of all life forms. The precise regulation of proliferation in response to internal and external cues is critical for development, tissue renewal and evolutionary fitness, while the disregulation of proliferation underlies many human conditions, most notably cancer and aging. Historically, the breakthroughs in our understanding of cell growth and division have derived from cross-fertilization of results and ideas from researchers studying sundry model organisms, from yeast to humans. The basis for cell proliferation entails the control of key signaling and cell cycle regulators through transcriptional, translational, post-translational, genetic and epigenetic mechanisms. Indeed, many conceptual breakthroughs in cell regulation have derived from analyses of basic cell cycle mechanisms. This Gordon Research Conference on the Molecular and Genetic Basis of Cell Proliferation aims to provide an integrated perspective on the multitude of processes that govern cell growth and division across a spectrum of eukaryotic model systems. Many frontiers of cell division research will be covered, including fundamental cell cycle modules, checkpoints and cancer, chromosome replication and dynamics, control of cell growth and polarity, growth factors and signal transduction, ubiquitin-dependent proteolysis, gene regulation and systems-level approaches. This meeting affords an opportunity to access an interdisciplinary cross-section of cell cycle research as presented by international leaders in their respective fields. In recent past meetings, discussion has been lively as researchers exchange their diverse perspectives on cell proliferation. Participation from meeting applicants will be encouraged through the selection of several short talks from the submitted abstracts. To submit an abstract please use the GRC Online Conference Application Form. |
SUNDAY | |
2:00 pm - 9:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Keynote Speakers |
Discussion Leader: Mike Tyers | |
7:30 pm - 8:30 pm | Gerard Evan "Putting the brakes on tumor cell growth" |
8:30 pm - 9:30 pm | Steve Elledge (Harvard Medical School) "Adventures in mammalian genetics" |
MONDAY | |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Growth |
Discussion Leader: Bruce Edgar | |
9:00 am - 9:30 am | Bruce Edgar (Fred Hutchinson Cancer Research Center) "Proliferation and growth control in Drosophila" |
9:30 am - 10:00 am | Mike Hall (University of Basel) "TOR signaling and control of cell growth in yeast and mammals" |
10:00 am - 10:30 am | Morris Birnbaum (HHMI/U of Pennsylvania) "Regulation of growth and metabolism by Akt/PKB" |
10:30 am | Coffee Break / Photo |
11:00 am - 11:30 am | George Thomas (U Cinncinati) "The nutrient input to the mTOR/S6K1 signaling pathway" |
11:30 am - 12:00 pm | Laura Johnston (Columbia University) "Growth, competition and size control" |
12:00 pm - 12:15 pm | Karen Cichowski (Harvard Medical School) "The NF1 tumour suppressor is an indispensable regulator of TSc2 and mTOR" |
12:15 pm - 12:30 pm | Brendan Manning (Harvard School of Public Health) "Feedback inhibition of Akt signaling limits the growth of tumors lacking Tsc2" |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Signaling |
Discussion Leader: Tony Pawson | |
7:30 pm - 8:00 pm | Tony Pawson (Samuel Lunenfeld Research Institute) "Reciprocal cell signaling" |
8:00 pm - 8:15 pm | Larry Feig (Tufts University) "The Ral GTPase Signaling Cascade in Cellular Growth Control" |
8:15 pm - 8:30 pm | Anne-Claude Gingras (Institute for Systems Biology) "Comparative protein interaction networks for the PP2A-type phosphatases" |
8:30 pm - 9:00 pm | Helen McNeill (Cancer Research UK) "Drosophila tumour suppressor genes in growth & tissue organization" |
9:00 pm - 9:30 pm | Ben Neel (Beth Israel-Deaconess Medical Center, Harvard Medical School) "Shp2 and its binding proteins in cancer" |
TUESDAY | |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Cell Cycle |
Discussion Leader: Orna Cohen-Fix | |
9:00 am - 9:30 am | Orna Cohen-Fix (NIH) "Yeast with nuclei bent out of shape" |
9:30 am - 10:00 am | Wade Harper (Harvard Medical School) "Substrate recognition and ubiquitination by cullin-based ubiquitin ligases" |
10:00 am - 10:30 am | Helena Richardson (Peter Mac Cancer Institute, Australia) "Novel regulators of G1-S phase progression revealed in a Drosophila genetic screen" |
10:30 am | Coffee Break |
11:00 am - 11:30 am | Matthias Peter (ETH, Switzerland) "Regulation and function of cullin-based ligases" |
11:30 am - 12:00 pm | Joan Ruderman (Harvard Medical School) "Aurora kinases and mitosis" |
12:00 pm - 12:15 pm | Zhi-Chun Lai (Pennsylvania State University) "Control of Cell Proliferation and Apoptosis by Mob as Tumor Suppressor, Mats" |
12:15 pm - 12:30 pm | Eric Weiss (Northwestern University) "Regulation of yeast Cbk1 and its role in Ace2-driven transcriptional asymmetry" |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Chromosome Replication and Dynamics |
Discussion Leader: Titia de Lange (The Rockefeller University) | |
7:30 pm - 8:00 pm | Titia de Lange (The Rockefeller University) "How telomeres tame the DNA damage response" |
8:00 pm - 8:30 pm | John Diffley (Cancer Research UK) "Regulation of origin licensing in human cells by cyclin dependent kinases" |
8:30 pm - 9:00 pm | Dan Durocher (Samuel Lunenfeld Research Institute) "Control of checkpoint recovery by histone H2A dephosphorylation" |
9:00 pm - 9:15 pm | Yisong Wang (Oak Ridge National Laboratory) "Human Cdc14B phosphatase and microtubule dynamics" |
9:15 pm - 9:30 pm | TBA |
WEDNESDAY | |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Checkpoints |
Discussion Leader: Helen Piwnica-Worms | |
9:00 am - 9:30 am | Helen Piwnica-Worms (Washington University School of Medicine) "Mammalian cell cycle and checkpoint control" |
9:30 am - 10:00 am | Sally Kornbluth (Duke University Medical Center) "Checkpoint regulation of Cdc25" |
10:00 am - 10:30 am | Carol Prives (Columbia University) "Regulation of DNA damage mediated apoptosis by the p53 family" |
10:30 am | Coffee Break |
11:00 am - 11:30 am | Susan Lees-Miller (University of Calgary) "Mechanisms of Activation of ATM" |
11:30 am - 12:00 pm | Mike Yaffe (MIT) "MAPKAP Kinase-2/Chk3 - a critical regulator of DNA damage checkpoint signaling" |
12:00 pm - 12:30 pm | Robert Rottapel (Ontario Cancer Institute) "The Rho GEF Lfc Regulates Spindle Assembly in Early Mitosis" |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Systematics and Mathematical Modeling |
Discussion Leader: Fred Cross | |
7:30 pm - 8:00 pm | Fred Cross (The Rockefeller University) "Modeling the cell cycle: Top-down, bottom-up or lost in the middle" |
8:00 pm - 8:30 pm | Ravi Iyengar (Mount Sinai School of Medicine) "Regulatory motifs in cellular networks" |
8:30 pm - 9:00 pm | Rebecca Heald (University of California, Berkeley) "Mechanisms and molecules of mitosis" |
9:00 pm - 9:30 pm | Mike Snyder (Yale University) "Regulatory networks in eucaryotes" |
THURSDAY | |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Gene Regulation |
Discussion Leader: Dan Gottschling | |
9:00 am - 9:30 am | Dan Gottschling (Fred Hutchinson Cancer Research Center) "Nuclear incontinence: The effects of old age on the genome" |
9:30 am - 10:00 am | Nick Dyson (Beth Israel-Deaconess Medical Center, Harvard Medical School) "Varieties of E2F-mediated regulation" |
10:00 am - 10:30 am | Bill Tansey (Cold Spring Harbor Laboratory) "Transcriptional control and the ubiquitin-proteasome system" |
10:30 am | Coffee Break |
11:00 am - 11:30 am | Ali Shilatifard (Saint Louis University School of Medicine) "Yeast COMPASS points the way to human MLL and its role in the regulation of gene expression as a histone methyltransferase" |
11:30 am - 11:45 am | Stephane Larochelle (Memorial Sloan-Kettering Cancer Center) "The dual-function Cdk7 complex: exquisite specificity and cell cycle-dependent substrate selectivity revealed through chemical genetics" |
11:45 am - 12:00 pm | Randal Tibbetts (University of Wisconsin) "Mechanisms of CREB phosphorylation by ATM/ATR kinases" |
12:00 pm - 12:15 pm | Linda Penn (Ontario Cancer Institute) "Cul7 cooperates with Myc in transformation by promoting p53 ubiquitination and inhibiting p53 mediated apoptosis" |
12:15 pm - 12:30 pm | Business Meeting |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Cancer |
Discussion Leader: Tak Mak | |
7:30 pm - 8:00 pm | Tak Mak (Campbell Family Institute of Breast Cancer Research, Ontario Cancer Institute) "Regulation of PTEN functions" |
8:00 pm - 8:30 pm | Jackie Lees (MIT) "E2F in the control of proliferation and apoptosis" |
8:30 pm - 9:00 pm | Jean Y.J. Wang (University of California San Diego) "Death by Abl: A matter of location and translocation" |
9:00 pm - 9:30 pm | Dafna Bar-Sagi (SUNY at Stonybrook) "Ras signaling" |
FRIDAY | |
7:30 am - 8:30 am | Breakfast |
9:00 am | Depart |
Copyright © 2005 Gordon Research Conferences | Last Updated: 6/17/05 by Jeff Carroll |