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Research library: browse by date

March 2006

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The Research Library categorizes, and provides access to, all recent signaling-related research published in the Nature Publishing Group journals. The selection is deliberately broad to facilitate access to all research impacting on the signaling community. Both primary research and review articles are included, as are 'News and Views' articles.

Click here for free access to the 'Featured Articles' section, with new articles every week.

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Global landscape of protein complexes in the yeast Saccharomyces cerevisiae
Nevan J. Krogan, Gerard Cagney, Haiyuan Yu, Gouqing Zhong, Xinghua Guo, Alexandr Ignatchenko, Joyce Li, Shuye Pu, Nira Datta, Aaron P. Tikuisis, Thanuja Punna, José M. Peregrín-Alvarez, Michael Shales, Xin Zhang, Michael Davey, Mark D. Robinson, Alberto Paccanaro, James E. Bray, Anthony Sheung, Bryan Beattie, Dawn P. Richards, Veronica Canadien, Atanas Lalev, Frank Mena, Peter Wong, Andrei Starostine, Myra M. Canete, James Vlasblom, Samuel Wu, Chris Orsi, Sean R. Collins, Shamanta Chandran, Robin Haw, Jennifer J. Rilstone, Kiran Gandi, Natalie J. Thompson, Gabe Musso, Peter St Onge, Shaun Ghanny, Mandy H. Y. Lam, Gareth Butland, Amin M. Altaf-Ul, Shigehiko Kanaya, Ali Shilatifard, Erin O'Shea, Jonathan S. Weissman, C. James Ingles, Timothy R. Hughes, John Parkinson, Mark Gerstein, Shoshana J. Wodak, Andrew Emili and Jack F. Greenblatt
Nature 440, 637–643
(30 March 2006); doi:10.1038/nature04670
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A C. elegans stretch receptor neuron revealed by a mechanosensitive TRP channel homologue
Wei Li, Zhaoyang Feng, Paul W. Sternberg and X. Z. Shawn Xu
Nature 440, 684–687
(30 March 2006); doi:10.1038/nature04538
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Regulation of cancer cell migration and bone metastasis by RANKL
D. Holstead Jones , Tomoki Nakashima, Otto H. Sanchez, Ivona Kozieradzki , Svetlana V. Komarova, Ildiko Sarosi, Sean Morony, Evelyn Rubin, Renu Sarao, Carlo V. Hojilla, Vukoslav Komnenovic, Young-Yun Kong, Martin Schreiber, S. Jeffrey Dixon, Stephen M. Sims, Rama Khokha, Teiji Wada and Josef M. Penninger
Nature 440, 692–696
(30 March 2006); doi:10.1038/nature04524
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Analysis of a RanGTP-regulated gradient in mitotic somatic cells
Petr Kaláb, Arnd Pralle, Ehud Y. Isacoff, Rebecca Heald and Karsten Weis
Nature 440, 697–701
(30 March 2006); doi:10.1038/nature04589
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Oncogenic activity of Cdc6 through repression of the INK4/ARF locus
Susana Gonzalez, Peter Klatt, Sonia Delgado, Esther Conde, Fernando Lopez-Rios, Montserrat Sanchez-Cespedes, Juan Mendez, Francisco Antequera and Manuel Serrano
Nature 440, 702–706
(30 March 2006); doi:10.1038/nature04585
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The microRNA miR-181 targets the homeobox protein Hox-A11 during mammalian myoblast differentiation
Irina Naguibneva, Maya Ameyar-Zazoua, Anna Polesskaya, Slimane Ait-Si-Ali, Reguina Groisman, Mouloud Souidi, Sylvain Cuvellier & Annick Harel-Bellan
Nature Cell Biology 8, 278–284
(30 March 2006); doi:10.1038/ncb1373
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review article
A visual approach to proteomics
Stephan Nickell, Christine Kofler, Andrew P. Leis and Wolfgang Baumeister
Nature Reviews Molecular Cell Biology 7, 225–230
(30 March 2006); doi:10.1038/nrm1861
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review article
CATERPILLERs, pyrin and hereditary immunological disorders
Jenny P.-Y. Ting, Daniel L. Kastner and Hal M. Hoffman
Nature Reviews Immunology 6, 183–195
(March 2006); doi:10.1038/nri1788
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Anti-inflammatory actions of lipoxin A4 and aspirin-triggered lipoxin are SOCS-2 dependent
Fabiana S Machado, James E Johndrow, Lisia Esper, Alexandra Dias, Andre Bafica, Charles N Serhan & Julio Aliberti
Nature Medicine 12, 330–334
(March 2006); doi:10.1038/nm1355
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Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes
Struan F A Grant, Gudmar Thorleifsson, Inga Reynisdottir, Rafn Benediktsson, Andrei Manolescu, Jesus Sainz, Agnar Helgason, Hreinn Stefansson, Valur Emilsson, Anna Helgadottir, Unnur Styrkarsdottir, Kristinn P Magnusson, G Bragi Walters, Ebba Palsdottir, Thorbjorg Jonsdottir, Thorunn Gudmundsdottir, Arnaldur Gylfason, Jona Saemundsdottir, Robert L Wilensky, Muredach P Reilly, Daniel J Rader, Yu Bagger, Claus Christiansen, Vilmundur Gudnason, Gunnar Sigurdsson, Unnur Thorsteinsdottir, Jeffrey R Gulcher, Augustine Kong & Kari Stefansson
Nature Genetics 38, 320–323
(March 2006); doi:10.1038/ng1732
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article
Silencing of EphA3 through a cis interaction with ephrinA5
Ricardo F Carvalho, Martin Beutler, Katharine J M Marler, Bernd Knöll, Elena Becker-Barroso, R Heintzmann, Tony Ng & Uwe Drescher
Nature Neuroscience 9, 322–330
(March 2006); doi:10.1038/nn1655
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review article
Expanding insights of mitochondrial dysfunction in Parkinson's disease
Patrick M. Abou-Sleiman, Miratul M. K. Muqit and Nicholas W. Wood
Nature Reviews Neuroscience 7, 207–219
(March 2006); doi:10.1038/nrn1868
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Close membrane-membrane proximity induced by Ca2+-dependent multivalent binding of synaptotagmin-1 to phospholipids
Demet Araç, Xiaocheng Chen, Htet A Khant, Josep Ubach, Steven J Ludtke, Masahide Kikkawa, Arthur E Johnson, Wah Chiu, Thomas C Südhof & Josep Rizo
Nature Structural & Molecular Biology 13, 209–217
(March 2006); doi:10.1038/nsmb1056
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review article
Evolving knowledge and therapy of inflammatory bowel disease
Joshua R. Korzenik and Daniel K. Podolsky
Nature Reviews Drug Discovery 5, 197–209
(March 2006); doi:10.1038/nrd1986
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article
Challenges in deriving high-confidence protein identifications from data gathered by a HUPO plasma proteome collaborative study
David J States, Gilbert S Omenn, Thomas W Blackwell, Damian Fermin, Jimmy Eng, David W Speicher & Samir M Hanash
Nature Biotechnology 24, 333–338
(March 2006); doi:10.1038/nbt1183
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Human chromosome 11 DNA sequence and analysis including novel gene identification
Todd D. Taylor, Hideki Noguchi, Yasushi Totoki, Atsushi Toyoda, Yoko Kuroki, Ken Dewar, Christine Lloyd, Takehiko Itoh, Tadayuki Takeda, Dae-Won Kim, Xinwei She, Karen F. Barlow, Toby Bloom, Elspeth Bruford, Jean L. Chang, Christina A. Cuomo, Evan Eichler, Michael G. FitzGerald, David B. Jaffe, Kurt LaButti, Robert Nicol, Hong-Seog Park, Christopher Seaman, Carrie Sougnez, Xiaoping Yang, Andrew R. Zimmer, Michael C. Zody, Bruce W. Birren, Chad Nusbaum, Asao Fujiyama, Masahira Hattori, Jane Rogers, Eric S. Lander and Yoshiyuki Sakaki
Nature 440, 497–500
(23 March 2006); doi:10.1038/nature04632
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The prolyl isomerase Pin1 regulates amyloid precursor protein processing and amyloid-ß production
Lucia Pastorino, Anyang Sun , Pei-Jung Lu, Xiao Zhen Zhou, Martin Balastik, Greg Finn, Gerburg Wulf, Jormay Lim, Shi-Hua Li, Xiaojiang Li, Weiming Xia, Linda K. Nicholson and Kun Ping Lu
Nature 440, 528–534
(23 March 2006); doi:10.1038/nature04543
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A P-type ATPase required for rice blast disease and induction of host resistance
Martin J. Gilbert, Christopher R. Thornton, Gavin E. Wakley and Nicholas J. Talbot
Nature 440, 535–539
(23 March 2006); doi:10.1038/nature04567
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CD69 acts downstream of interferon- α/ß to inhibit S1P1 and lymphocyte egress from lymphoid organs
Lawrence R. Shiow , David B. Rosen, Nadêzda Brdicková, Ying Xu, Jinping An, Lewis L. Lanier, Jason G. Cyster and Mehrdad Matloubian
Nature 440, 540–544
(23 March 2006); doi:10.1038/nature04606
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An excitable gene regulatory circuit induces transient cellular differentiation
Gürol M. Süel, Jordi Garcia-Ojalvo, Louisa M. Liberman and Michael B. Elowitz
Nature 440, 545–550
(23 March 2006); doi:10.1038/nature04588
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CHIP-mediated stress recovery by sequential ubiquitination of substrates and Hsp70
Shu-Bing Qian, Holly McDonough, Frank Boellmann, Douglas M. Cyr and Cam Patterson
Nature 440, 551–555
(23 March 2006); doi:10.1038/nature04600
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RNA-mediated response to heat shock in mammalian cells
Ilya Shamovsky, Maxim Ivannikov, Eugene S. Kandel, David Gershon and Evgeny Nudler
Nature 440, 556–560
(23 March 2006); doi:10.1038/nature04518
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Endonucleolytic cleavage of eukaryotic mRNAs with stalls in translation elongation
Meenakshi K. Doma & Roy Parker
Nature 440, 561–564
(2006) doi:10.1038/nature04530
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Molecular biology: RNA lost in translation
David Tollervey
Nature 440, 425–426
(23 March 2006); doi:10.1038/440425a
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The Dam1 kinetochore ring complex moves processively on depolymerizing microtubule ends
Stefan Westermann, Hong-Wei Wang, Agustin Avila-Sakar, David G. Drubin, Eva Nogales and Georjana Barnes
Nature 440, 565–569
(23 March 2006); doi:10.1038/nature04409
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Cell division: Running rings around the spindle
Deepa Nath
Nature 440, 434
(23 March 2006); doi:10.1038/440434a
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Atomic structure of a Na+- and K+-conducting channel
Ning Shi, Sheng Ye, Amer Alam, Liping Chen and Youxing Jiang
Nature 440, 570–574
(23 March 2006); doi:10.1038/nature04508
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Membrane biology: Permutations of permeability
William N. Zagotta
Nature 440, 427–429
(23 March 2006); doi:10.1038/440427a
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Intracellular trafficking and proteolysis of the Arabidopsis auxin-efflux facilitator PIN2 are involved in root gravitropism
Lindy Abas, René Benjamins, Nenad Malenica, Tomasz Paciorek, Justyna Wiřniewska, Jeanette C. Moulinier-Anzola, Tobias Sieberer, Jiří Friml and Christian Luschnig
Nature Cell Biology 8, 249–256
(March 2006); doi:10.1038/ncb1369
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review article
Cell-signalling dynamics in time and space
Boris N. Kholodenko
Nature Reviews Molecular Cell Biology 7, 165–176
(March 2006); doi:10.1038/nrm1838
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article
Monocyte emigration from bone marrow during bacterial infection requires signals mediated by chemokine receptor CCR2
Natalya V Serbina and Eric G Pamer
Nature Immunology 7, 311–317
(March 2006); doi:10.1038/ni1309
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article
Viral nanoparticles as tools for intravital vascular imaging
John D Lewis, Giuseppe Destito, Andries Zijlstra, Maria J Gonzalez, James P Quigley, Marianne Manchester and Heidi Stuhlmann
Nature Medicine 12, 354–360
(March 2006); doi:10.1038/nm1368
| Abstract | Full Text (HTML/PDF) |

review article
Beyond PTEN mutations: the PI3K pathway as an integrator of multiple inputs during tumorigenesis
Megan Cully , Han You, Arnold J. Levine and Tak W. Mak
Nature Reviews Cancer 6, 184–192
(March 2006); doi:10.1038/nrc1819
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review article
Signaling protein complexes associated with neuronal ion channels
Irwin B Levitan
Nature Neuroscience 13, 278–284
(March 2006); doi:10.1038/nn1647
| Abstract | Full Text (HTML/PDF) |

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Recognition of helical kinks by xeroderma pigmentosum group A protein triggers DNA excision repair
Ulrike Camenisch, Ramiro Dip, Sylvie Briand Schumacher, Benjamin Schuler and Hanspeter Naegeli
Nature Structural and Molecular Biology 13, 278–284
(March 2006); doi:10.1038/nsmb1061
| Abstract | Full Text (HTML/PDF) |

review article
Adenosine receptors as therapeutic targets
Kenneth A. Jacobson and Zhan-Guo Gao
Nature Reviews Drug Discovery 5, 247–264
(March 2006); doi:10.1038/nrd1983
| Summary | Full Text (HTML / PDF) |

research article
Neurotrophins mediate human embryonic stem cell survival
April D Pyle, Leslie F Lock and Peter J Donovan
Nature Biotechnology 24, 344–350
(March 2006); doi:10.1038/nbt1189
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research article
CD30 is a survival factor and a biomarker for transformed human pluripotent stem cells
Daniella Herszfeld, Ernst Wolvetang, Emma Langton-Bunker, Tung-Liang Chung, Adam A Filipczyk, Souheir Houssami, Pegah Jamshidi, Karen Koh, Andrew L Laslett, Anna Michalska, Linh Nguyen, Benjamin E Reubinoff, Irene Tellis, Jonathan M Auerbach, Carol J Ording, Leendert H J Looijenga and Martin F Pera
Nature Biotechnology 24, 351–357
(March 2006); doi:10.1038/nbt1197
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news and views
The selfish stem cell
Peter W Andrews
Nature Biotechnology 24, 325–326
(March 2006); doi:10.1038/nbt0306-325
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Robust Salmonella metabolism limits possibilities for new antimicrobials
Daniel Becker, Matthias Selbach, Claudia Rollenhagen, Matthias Ballmaier, Thomas F. Meyer, Matthias Mann and Dirk Bumann
Nature 440, 303–307
(16 March 2006); doi:10.1038/nature04616
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A specific amyloid-β protein assembly in the brain impairs memory
Sylvain Lesné, Ming Teng Koh, Linda Kotilinek, Rakez Kayed, Charles G. Glabe, Austin Yang, Michela Gallagher and Karen H. Ashe
Nature 440, 352–357
(16 March 2006); doi:10.1038/nature04533
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news and views
Alzheimer's disease: A needle from the haystack
Richard Morris and Lennart Mucke
Nature 440, 284–285
(16 March 2006); doi:10.1038/440284a
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Stochastic protein expression in individual cells at the single molecule level
Long Cai, Nir Friedman and X. Sunney Xie
Nature 440, 358–362
(16 March 2006); doi:10.1038/nature04599
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The PerR transcription factor senses H2O2 by metal-catalysed histidine oxidation
Jin-Won Lee and John D. Helmann
Nature 440, 363–367
(16 March 2006); doi:10.1038/nature04537
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GM130 and GRASP65-dependent lateral cisternal fusion allows uniform Golgi-enzyme distribution
Manojkumar A. Puthenveedu, Collin Bachert, Sapna Puri, Frederick Lanni and Adam D. Linstedt
Nature Cell Biology 8, 238–248
(March 2006); doi:10.1038/ncb1366
| Abstract | Full Text (HTML/PDF) |

review article
Building mammalian signalling pathways with RNAi screens
Jason Moffat and David M. Sabatini
Nature Reviews Molecular Cell Biology 7, 177–187
(March 2006); doi:10.1038/nrm1860
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Particularities of the vasculature can promote the organ specificity of autoimmune attack
Bryce A Binstadt, Pratik R Patel, Herlen Alencar, Peter A Nigrovic, David M Lee, Umar Mahmood, Ralph Weissleder, Diane Mathis and Christophe Benoist
Nature Immunology 7, 284–292
(March 2006); doi:10.1038/ni1306
| Abstract | Full Text (HTML/PDF) |

review article
cFLIP regulation of lymphocyte activation and development
Ralph C. Budd, Wen-Chen Yeh and Jürg Tschopp
Nature Reviews Immunology 6, 196–204
(March 2006); doi:10.1038/nri1787
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A novel peptide CXCR ligand derived from extracellular matrix degradation during airway inflammation
Nathaniel M Weathington, Anneke H van Houwelingen, Brett D Noerager, Patricia L Jackson, Aletta D Kraneveld, F Shawn Galin, Gert Folkerts, Frans P Nijkamp and J Edwin Blalock
Nature Medicine 12, 317–323
(March 2006); doi:10.1038/nm1361
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news and views
The matrix degrades, neutrophils invade
Peter M Henson, R William Vandivier
Nature Medicine 12, 280–281
(2006); doi:10.1038/nm0306-280
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Feedback repression is required for mammalian circadian clock function
Trey K Sato, Rikuhiro G Yamada, Hideki Ukai, Julie E Baggs, Loren J Miraglia, Tetsuya J Kobayashi, David K Welsh, Steve A Kay, Hiroki R Ueda and John B Hogenesch
Nature Genetics 38, 312–319
(March 2006); doi:10.1038/ng1745
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review article
Microarray technology: beyond transcript profiling and genotype analysis
Jörg D. Hoheisel
Nature Reviews Genetics 7, 200–210
(March 2006); doi:10.1038/nrg1809
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review article
Illuminating insights into protein-protein interactions using bioluminescence resonance energy transfer (BRET)
Kevin D G Pfleger and Karin A Eidne
Nature Methods 3, 165–174
(March 2006); doi:10.1038/nmeth841
| Abstract | Full Text (HTML/PDF) |

review article
Prions and their lethal journey to the brain
Neil A. Mabbott and G. Gordon MacPherson
Nature Reviews Microbiology 4, 201–211
(March 2006); doi:10.1038/nrmicro1346
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review article
An APRIL to remember: novel TNF ligands as therapeutic targets
Stacey R. Dillon, Jane A. Gross, Stephen M. Ansell and Anne J. Novak
Nature Reviews Drug Discovery 5, 235–246
(March 2006); doi:10.1038/nrd1982
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ClC-7 requires Ostm1 as a ß-subunit to support bone resorption and lysosomal function
Philipp F. Lange, Lena Wartosch, Thomas J. Jentsch and Jens C. Fuhrmann
Nature 440, 220–223
(09 March 2006); doi:10.1038/nature04535
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Cryopyrin activates the inflammasome in response to toxins and ATP
Sanjeev Mariathasan, David S. Weiss, Kim Newton, Jacqueline McBride, Karen O'Rourke, Meron Roose-Girma, Wyne P. Lee, Yvette Weinrauch, Denise M. Monack and Vishva M. Dixit
Nature 440, 228–232
(09 March 2006); doi:10.1038/nature04515
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Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3
Thirumala-Devi Kanneganti, Nesrin Özören, Mathilde Body-Malapel, Amal Amer, Jong-Hwan Park, Luigi Franchi, Joel Whitfield, Winfried Barchet, Marco Colonna, Peter Vandenabeele, John Bertin, Anthony Coyle, Ethan P. Grant, Shizuo Akira and Gabriel Núñez
Nature 440, 233–236
(09 March 2006); doi:10.1038/nature04517
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Gout-associated uric acid crystals activate the NALP3 inflammasome
Fabio Martinon, Virginie Pétrilli, Annick Mayor, Aubry Tardivel and Jürg Tschopp
Nature 440, 237–241
(09 March 2006); doi:10.1038/nature04516
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article
Myosin II functions in actin-bundle turnover in neuronal growth cones
Nelson A. Medeiros, Dylan T. Burnette and Paul Forscher
Nature Cell Biology 8, 216–226
(March 2006); doi:10.1038/ncb1367
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review article
Structural systems biology: modelling protein interactions
Patrick Aloy and Robert B. Russell
Nature Reviews Molecular Cell Biology 7, 188–197
(March 2006); doi:10.1038/nrm1859
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Positive regulation of immune cell function and inflammatory responses by phosphatase PAC-1
Kate L Jeffrey, Tilman Brummer, Michael S Rolph, Sue M Liu, Nuria A Callejas, Raelene J Grumont, Corine Gillieron, Fabienne Mackay, Shane Grey, Montserrat Camps, Christian Rommel, Steve D Gerondakis and Charles R Mackay
Nature Immunology 7, 274–283
(March 2006); doi:10.1038/ni1310
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review article
Integrated signalling pathways for mast-cell activation
Alasdair M. Gilfillan and Christine Tkaczyk
Nature Reviews Immunology 6, 218–230
(March 2006); doi:10.1038/nri1782
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Disruption of PTEN coupling with 5-HT2C receptors suppresses behavioral responses induced by drugs of abuse
Shao-Ping Ji, Yun Zhang, Jamie Van Cleemput, Wen Jiang, Mingxia Liao, Lei Li, Qi Wan, Jon R Backstrom and Xia Zhang
Nature Medicine 12, 324–329
(March 2006); doi:10.1038/nm1349
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news and views
Plot against pot
Kerrie L Thomas
Nature Medicine 12, 281–283
(March 2006); doi:10.1038/nm0306-281
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review article
ASPPs and cancer
Giuseppe Trigiante and Xin Lu
Nature Reviews Cancer 6, 217–226
(March 2006); doi:10.1038/nrc1818
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news and views
Pooling in systems biology becomes smart
Nicolas Thierry-Mieg
Nature Methods 3, 161–162
(March 2006); doi:10.1038/nmeth0306-161
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A pooling-deconvolution strategy for biological network elucidation
Fulai Jin, Tony Hazbun, Gregory A Michaud, Michael Salcius, Paul F Predki, Stanley Fields and Jing Huang
Nature Methods 3, 183–189
(March 2006); doi:10.1038/nmeth859
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review article
N6-methyl-adenine: an epigenetic signal for DNA-protein interactions
Didier Wion and Josep Casadesús
Nature Reviews Microbiology 4, 183–192
(March 2006); doi:10.1038/nrmicro1350
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article
Structural basis for ubiquitin recognition and autoubiquitination by Rabex-5
Sangho Lee, Yien Che Tsai, Rafael Mattera, William J Smith, Michael S Kostelansky, Allan M Weissman, Juan S Bonifacino and James H Hurley
Nature Structural and Molecular Biology 13, 264–271
(March 2006); doi:10.1038/nsmb1064
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article
Double-sided ubiquitin binding of Hrs-UIM in endosomal protein sorting
Satoshi Hirano, Masato Kawasaki, Hideaki Ura, Ryuichi Kato, Camilla Raiborg, Harald Stenmark and Soichi Wakatsuki
Nature Structural and Molecular Biology 13, 272–277
(March 2006); doi:10.1038/nsmb1051
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news and views
U2
Steven L Alam and Wesley I Sundquist
Nature Structural and Molecular Biology 13, 186–188
(March 2006); doi:10.1038/nsmb0306-186
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review article
Targeting multidrug resistance in cancer
Gergely Szakács, Jill K. Paterson, Joseph A. Ludwig, Catherine Booth-Genthe
Nature Reviews Drug Discovery 5, 219–234
(March 2006); doi:10.1038/nrd1984
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article
Optimal isotope labelling for NMR protein structure determinations
Masatsune Kainosho, Takuya Torizawa, Yuki Iwashita, Tsutomu Terauchi, Akira Mei Ono and Peter Güntert
Nature 440, 52–57
(02 March 2006); doi:10.1038/nature04525
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news and views
Structural biology: Designer labels
Stanley J. Opella
Nature 440, 40
(02 March 2006); doi:10.1038/440040a
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Mitoferrin is essential for erythroid iron assimilation
George C. Shaw, John J. Cope, Liangtao Li, Kenneth Corson, Candace Hersey, Gabriele E. Ackermann, Babette Gwynn, Amy J. Lambert, Rebecca A. Wingert, David Traver, Nikolaus S. Trede, Bruce A. Barut, Yi Zhou, Emmanuel Minet, Adriana Donovan, Alison Brownlie, Rena Balzan, Mitchell J. Weiss, Luanne L. Peters, Jerry Kaplan, Leonard I. Zon and Barry H. Paw
Nature 440, 96–100
(02 March 2006); doi:10.1038/nature04512
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How guanylate-binding proteins achieve assembly-stimulated processive cleavage of GTP to GMP
Agnidipta Ghosh, Gerrit J. K. Praefcke, Louis Renault, Alfred Wittinghofer and Christian Herrmann
Nature 440, 101–104
(02 March 2006); doi:10.1038/nature04510
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Development of the signal in sensory rhodopsin and its transfer to the cognate transducer
Rouslan Moukhametzianov , Johann P. Klare, Rouslan Efremov, Christian Baeken, Annika Göppner, Jörg Labahn, Martin Engelhard, Georg Büldt and Valentin I. Gordeliy
Nature 440, 115–119
(02 March 2006); doi:10.1038/nature04520
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news and views
Cell biology: Ageing nucleus gets out of shape
Hannes Lans and Jan H. J. Hoeijmakers
Nature 440, 32–34
(02 March 2006); doi:10.1038/440032a
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news and views
Cell Biology: A break in the chain?
Keith Burridge
Nature 440, 38
(02 March 2006); doi:10.1038/440038b
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Retinoic-acid signalling in node ectoderm and posterior neural plate directs left-right patterning of somitic mesoderm
Ioan Ovidiu Sirbu and Gregg Duester
Nature Cell Biology 8, 271–277
(March 2006); doi:10.1038/ncb1374
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review article
The model organism as a system: integrating 'omics' data sets
Andrew R. Joyce and Bernhard Ø. Palsson
Nature Reviews Molecular Cell Biology 7, 198–210
(March 2006); doi:10.1038/nrm1857
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article
T cells use two directionally distinct pathways for cytokine secretion
Morgan Huse, Björn F Lillemeier, Michael S Kuhns, Daniel S Chen and Mark M Davis
Nature Immunology 7, 247–255
(March 2006); doi:10.1038/ni1304
| Abstract | Full Text (HTML/PDF) |

review article
Antiviral antibody responses: the two extremes of a wide spectrum
Lars Hangartner, Rolf M. Zinkernagel and Hans Hengartner
Nature Reviews Immunology 6, 231–243
(March 2006); doi:10.1038/nri1783
| Summary | Full Text (HTML / PDF) |

article
Ciliogenesis defects in embryos lacking inturned or fuzzy function are associated with failure of planar cell polarity and Hedgehog signaling
Tae Joo Park, Saori L Haigo and John B Wallingford
Nature Genetics 38, 303–311
(March 2006); doi:10.1038/ng1753
| Abstract | Full Text (HTML/PDF) |

news and views
Hedgehogs on the road to polarity
Philip L Beales
Nature Genetics 38, 277–279
(March 2006); doi:10.1038/ng0306-277
| Full Text (HTML/PDF) |

review article
Genetic susceptibility to coronary artery disease: from promise to progress
Hugh Watkins and Martin Farrall
Nature Reviews Genetics 7, 163–173
(March 2006); doi:10.1038/nrg1805
| Summary | Full Text (HTML / PDF) |

article
Pigment epithelium-derived factor is a niche signal for neural stem cell renewal
Carmen Ramírez-Castillejo, Francisco Sánchez-Sánchez, Celia Andreu-Agulló, Sacri R Ferrón, J Daniel Aroca-Aguilar, Pilar Sánchez, Helena Mira, Julio Escribano and Isabel Fariñas
Nature Neuroscience 9, 331–339
(March 2006); doi:10.1038/nn1657
| Abstract | Full Text (HTML/PDF) |

news and views
PEDF: bridging neurovascular interactions in the stem cell niche
Kevin Pumiglia and Sally Temple
Nature Neuroscience 9, 299–300
(March 2006); doi:10.1038/nn0306-299
| Full Text (HTML/PDF) |

article
Fluorescence protease protection of GFP chimeras to reveal protein topology and subcellular localization
Holger Lorenz, Dale W Hailey and Jennifer Lippincott-Schwartz
Nature Methods 3, 205–210
(March 2006); doi:10.1038/nmeth857
| Full Text (HTML/PDF) |

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