SMRITI*: Episodic Memory Formation in the Hippocampal System
From Transient Patterns
to Persistent Structures
Our ability to remember events in our daily life and acquire specific facts
after reading a newspaper or watching a newscast underscores our ability
to rapidly acquire new memories. In general, these memories encode who
did what to whom where and when, and have
been described as episodic memories.
Neuropsychological, anatomical, and
physiological data suggests that the hippocampal system
(HS) plays a critical role in the encoding and retrieval of such memories.
But how the HS subserves
this mnemonic function is not fully understood.
is a computational model that demonstrates how a cortically
expressed transient pattern of rhythmic
activity representing an event or a situation
can be rapidly transformed into a persistent and robust memory trace as
a result of long-term potentiation and long-term depression
whose architecture and circuitry are consistent with those of the HS.
For more details see
This research has been partially supported by NSF grants SBR-9720398 and
ECS-9970890, and ONR grant N00014-93-1-1149.
* System for the memorization
of relational instances from temporal
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the views of the National Science Foundation.